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KMID : 0617220000110010035
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Duksung Bulletin Phamaceutical Sciences
2000 Volume.11 No. 1 p.35 ~ p.41
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Synthesis of Allylthiopyridazine Derivatives and their Protective Effects of UV-C Irradiation
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Abstract
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Four 3-alkoxy-6-allylthiopyridazines and 3-chloro-6-allylthiopyridazine were synthesized and their protective effects against oxidative stress and UV-C irradiation were tested. 3-Methoxy-6-allylthiopyridazine and 3-ethoxy-6-allylthiopyridazine did not show protective effect on the oxidative stress but showed the strongest protective effect on UV-C irradiation among the tested compounds. Especially 500 ㎍/㎖ of the two compounds was the most effective concentration.
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